Human post-mortem striatal α4β2 nicotinic acetylcholine receptor density in schizophrenia and Parkinson's syndrome
Identifieur interne : 001C22 ( Main/Exploration ); précédent : 001C21; suivant : 001C23Human post-mortem striatal α4β2 nicotinic acetylcholine receptor density in schizophrenia and Parkinson's syndrome
Auteurs : Nuria Durany [Espagne, Allemagne, États-Unis] ; Robert Zöchling [Allemagne] ; Karl W. Boissl [Allemagne] ; Werner Paulus [Allemagne] ; Gerhard Ransmayr [Autriche] ; Thomas Tatschner [Allemagne] ; Walter Danielczyk [Autriche] ; Kurt Jellinger [Autriche] ; Jürgen Deckert [Allemagne] ; Peter Riederer [Allemagne]Source :
- Neuroscience Letters [ 0304-3940 ] ; 2000.
English descriptors
Abstract
The density of nicotinic α4β2 receptors, which are believed to largely mediate nicotine's effects, has been reported to be decreased in post-mortem hippocampus of patients with schizophrenia. In the present study, using [3H]cytisine as a radioligand, we observed a significant 30% decrease in post-mortem striatum of patients with schizophrenia (n=12) as compared to controls (n=12). A 25% decrease of striatal α4β2 receptor density in patients with Parkinson's syndrome (n=12) was not significant. As an upregulation of α4β2 receptors has been observed due to nicotine consumption, the beneficial effects of nicotine described in patients with schizophrenia may be partly due to a compensation for a decrease in α4β2 nicotinic acetylcholine receptors.
Url:
DOI: 10.1016/S0304-3940(00)01144-7
Affiliations:
- Allemagne, Autriche, Espagne, États-Unis
- Bavière, Catalogne, District de Basse-Franconie, District de Münster, Rhénanie-du-Nord-Westphalie, Vienne (Autriche)
- Münster, Vienne (Autriche), Wurtzbourg
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schizophrenia. In the present study, using [3H]cytisine as a radioligand, we observed a significant 30% decrease in post-mortem striatum of patients with schizophrenia (n=12) as compared to controls (n=12). A 25% decrease of striatal α4β2 receptor density in patients with Parkinson's syndrome (n=12) was not significant. As an upregulation of α4β2 receptors has been observed due to nicotine consumption, the beneficial effects of nicotine described in patients with schizophrenia may be partly due to a compensation for a decrease in α4β2 nicotinic acetylcholine receptors.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Espagne</li><li>États-Unis</li></country><region><li>Bavière</li><li>Catalogne</li><li>District de Basse-Franconie</li><li>District de Münster</li><li>Rhénanie-du-Nord-Westphalie</li><li>Vienne (Autriche)</li></region><settlement><li>Münster</li><li>Vienne (Autriche)</li><li>Wurtzbourg</li></settlement></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Durany, Nuria" sort="Durany, Nuria" uniqKey="Durany N" first="Nuria" last="Durany">Nuria Durany</name></region></country><country name="Allemagne"><region name="Bavière"><name sortKey="Durany, Nuria" sort="Durany, Nuria" uniqKey="Durany N" first="Nuria" last="Durany">Nuria Durany</name></region><name sortKey="Boissl, Karl W" sort="Boissl, Karl W" uniqKey="Boissl K" first="Karl W" last="Boissl">Karl W. 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